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Biopharma CQV Consulting · Cary, NC

Precision Validation
Uncompromising Compliance

Aetresin LLC delivers expert Commissioning, Qualification & Validation services to biopharmaceutical manufacturers. We translate regulatory complexity into lifecycle-ready documentation.

5+
Years GMP Experience
50+
Protocols Executed
100%
Regulatory Readiness
Scroll
IQ · OQ · PQ Qualification
Cleaning Validation
MES Integration
21 CFR Part 11
FDA & EMA Compliance
Risk Management
Deviation Handling
Protocol Authoring
IQ · OQ · PQ Qualification
Cleaning Validation
MES Integration
21 CFR Part 11
FDA & EMA Compliance
Risk Management
Deviation Handling
Protocol Authoring

Built on precision,
driven by expertise

Aetresin LLC is a specialized CQV consultancy founded by industry veterans with deep roots in biopharmaceutical manufacturing and regulatory affairs.

We bring hands-on GMP experience from large-scale biologics facilities to your validation programs — delivering protocols that withstand FDA scrutiny and accelerate your path to production.

Our work spans equipment qualification, utility systems, MES platforms, and cleaning validation — with a disciplined, risk-based approach baked into every deliverable.

GMP Expertise

Deep experience across biologics, sterile fill-finish, and API manufacturing environments.

📋

Protocol Excellence

IQ/OQ/PQ documents that meet the exacting standards of modern regulatory agencies.

🔗

MES Integration

Syncade and Kneat platform expertise for paperless validation execution.

🛡

Risk-Based Approach

FMEA-grounded risk assessments aligned to ICH Q9 and ASTM E2500.

Core Services

01

Equipment & Utility Qualification

IQ, OQ, and PQ protocols for HPLC, lyophilizers, autoclaves, AHUs, and process utilities. Full lifecycle documentation from URS to Summary Report.

Learn More
02

Cleaning Validation

Scientifically defensible cleaning validation programs with HBEL-based acceptance criteria, swab/rinse sampling, and recovery studies.

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03

MES Integration & Validation

Syncade and Kneat platform configuration, URS mapping, and electronic batch record validation compliant with 21 CFR Part 11.

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04

Deviation & Risk Management

CAPA development, FMEA facilitation, and deviation investigation support to maintain continuous regulatory readiness.

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05

Change Control Support

Impact assessments, requalification scoping, and documentation packages for equipment, process, and facility changes.

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06

Regulatory Strategy & Compliance

Audit readiness assessments, inspection preparation, and gap analyses against 21 CFR Parts 210/211, EU GMP, and ICH guidelines.

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A

NC

Cary, North Carolina

The Aetresin
Difference

01

Lead-Level Accountability

Every engagement is personally managed by a senior CQV professional — not delegated to junior staff. You get the expertise you contracted for, every time.

02

Facility-Embedded Experience

Our work history includes large-scale biologics CDMOs, sterile manufacturing, and specialty pharmaceutical sites — we understand real-world production pressures.

03

Documentation Built to Survive Inspections

Every protocol, summary report, and deviation record is authored with regulatory defense in mind. We write for the inspector, not just the reviewer.

04

Flexible Engagement Models

From project-based scopes to ongoing retainer support, Aetresin adapts to your timeline, budget, and team structure without long-term bureaucracy.

Experience Gained At
CDMO · Biologics
Fujifilm
Diosynth Biotechnologies
Large-Scale Biologics CDMO
Equipment & utility qualification, MES validation, IQ/OQ/PQ protocol execution for bioreactor and downstream processing systems.
Specialty Pharma
Lohmann
Therapy Systems
Transdermal Drug Delivery
Qualification of coating, laminating, and packaging equipment; cleaning validation; deviation management in a GMP specialty pharma environment.
Sterile Mfg.
Fresenius
Kabi
IV Solutions & Sterile Fill-Finish
Sterile manufacturing qualification, lyophilizer and autoclave IQ/OQ/PQ, cleaning validation, and regulatory compliance support under 21 CFR Part 211.

Company names referenced for prior employment experience only. Not an implied endorsement or partnership.

Ready to elevate your validation program?

Whether you need a single protocol or a full site qualification program, Aetresin delivers with precision and speed.

About Aetresin

A firm built on real experience

Aetresin LLC
Cary, North Carolina
Est. May 2025

Aetresin LLC was founded in 2025 with a clear mandate: to bring senior-level CQV expertise directly to biopharmaceutical clients who need it most — without the overhead, bureaucracy, or diluted talent of large consulting firms.

The name Aetresin is a deliberate fusion — drawing from the founders' heritage and identity, forged into a single, distinctive mark that represents a new standard in validation consulting.

"Every protocol we write is a promise — to our clients, to patients, and to the integrity of the manufacturing process itself."

Our leadership brings five-plus years of hands-on GMP experience spanning large-scale biologics CDMOs, sterile manufacturing, specialty pharmaceuticals, and multi-site validation programs. We have personally authored and executed validation protocols across IQ/OQ/PQ, cleaning validation, MES platforms, and utility qualification — in environments where FDA inspection readiness is a daily operational standard.

We founded Aetresin to serve clients who want a true subject-matter expert in the room, not a project manager directing junior staff from a distance. Every engagement is led personally by our principals, ensuring consistency, accountability, and technical depth from kickoff through final report.

Based in Cary, North Carolina — in the heart of Research Triangle Park's thriving biopharma corridor — Aetresin is positioned to support both local clients and national engagements.

The principles that guide us

Integrity

We write what the data supports. No shortcuts, no ambiguity, no regulatory shortcuts to meet a deadline.

🎯

Precision

Validation is detail work. We treat every acceptance criterion, every test step, and every data entry with exacting care.

🤝

Partnership

We embed as part of your team — learning your systems, your timelines, and your priorities to deliver work that truly fits.

🔬

Science-First

Every validation decision is anchored in scientific rationale, not just regulatory checkbox compliance.

Meet the team

SS

Satyam Singh

Managing Member · CQV Lead

Satyam brings over five years of GMP biopharma experience spanning equipment and utility qualification, cleaning validation, MES integration, and regulatory compliance. He has served as CQV Lead across biologics CDMOs, specialty pharma, and sterile manufacturing sites, personally authoring and executing 50+ IQ/OQ/PQ protocols.

His technical scope spans HPLC, lyophilizers, autoclaves, AHUs, filling lines, and process utilities. He holds expertise in Syncade and Kneat MES platforms, 21 CFR Part 11 compliance, and FMEA-driven risk assessments.

IQ/OQ/PQ Cleaning Validation Syncade Kneat FMEA 21 CFR 211
CT

Celeste Treviño

Member · Operations

Celeste serves as the operational backbone of Aetresin LLC, overseeing business development, client relations, and organizational strategy. Her leadership ensures that every client engagement is supported by a structured, responsive, and professionally managed experience from initiation to close-out.

Together, Satyam and Celeste have built Aetresin to be a firm where rigorous technical execution meets seamless project management — delivering validation programs that are both scientifically defensible and operationally smooth.

Business Development Client Relations Operations Strategy

Built on a foundation of proven work

Fujifilm Diosynth Biotechnologies
Lohmann Therapy Systems
Fresenius Kabi
Research Triangle Park, NC
M.S. Biochemistry
B.S. Biotechnology
Six Sigma Black Belt (In Progress)
GMP Manufacturing · 5+ Years
CDMO · Biologics
Fujifilm
Diosynth Biotechnologies
Large-Scale Biologics CDMO
IQ/OQ/PQ for bioreactor, downstream processing, and utility systems. MES validation and electronic batch record implementation.
Specialty Pharma
Lohmann
Therapy Systems
Transdermal Drug Delivery
Equipment qualification for coating and packaging lines. Cleaning validation, deviation investigation, and change control support.
Sterile Mfg.
Fresenius
Kabi
IV Solutions & Sterile Fill-Finish
Lyophilizer and autoclave qualification, sterile manufacturing compliance, and 21 CFR Part 211 regulatory readiness.

Company names referenced for prior employment experience only. Not an implied endorsement or partnership.

Our Services

Comprehensive CQV capabilities

01

Equipment & Utility Qualification

We author and execute IQ, OQ, and PQ protocols for the full spectrum of biopharmaceutical manufacturing equipment — from analytical instrumentation to critical process systems. Each protocol is risk-stratified, aligned to current regulatory expectations, and designed for sustainable lifecycle management.

  • HPLC & Analytical Instruments
  • Lyophilizers
  • Autoclaves & Sterilizers
  • AHUs & HVAC
  • WFI & Purified Water
  • Filling Lines
  • Fermenters & Bioreactors
  • Centrifuges
IQ · OQ · PQ
02

Cleaning Validation

We develop comprehensive cleaning validation programs grounded in HBEL/PDE-based acceptance criteria, validated analytical methods, and robust sampling strategies. Our programs are built to satisfy 21 CFR Part 211.67, EU GMP Annex 15, and EMA guidelines on cleaning validation.

  • HBEL/PDE Calculations
  • Swab & Rinse Sampling
  • Recovery Studies
  • Worst-Case Equipment Selection
  • Cleaning Procedure Development
  • Analytical Method Validation
Lifecycle Validation
03

MES Integration & Validation

Aetresin has direct hands-on experience with Syncade and Kneat MES platforms. We manage the full validation lifecycle of electronic batch record systems — from URS authoring and equivalency analysis through configuration verification, UAT execution, and 21 CFR Part 11 compliance assessment.

  • Syncade Configuration
  • Kneat Platform Validation
  • URS Authoring & Mapping
  • UAT Execution
  • 21 CFR Part 11 Assessment
  • Electronic Batch Records
CSV · Part 11
04

Deviation & Risk Management

We support root cause investigation, CAPA development, and FMEA facilitation for validation deviations and quality events. Our risk management approach is ICH Q9-aligned, providing scientifically defensible documentation that protects your facility during regulatory review.

  • FMEA Facilitation
  • Root Cause Analysis
  • CAPA Development
  • ICH Q9 Alignment
  • Risk Assessment Reports
  • Deviation Investigation
ICH Q9 · CAPA
05

Change Control Support

Equipment changes, process modifications, and facility updates all trigger validation impact assessments. We scope requalification requirements, manage the technical rationale, and produce the documentation package to close change controls cleanly and compliantly.

  • Impact Assessments
  • Requalification Scoping
  • Change Control Documentation
  • Technical Rationale Authoring
Change Management
06

Regulatory Strategy & Audit Readiness

We conduct gap analyses against FDA 21 CFR 210/211, EU GMP, and ICH guidelines, and prepare your validation documentation for regulatory inspection. Aetresin can serve as a subject matter expert during internal audits, mock inspections, and actual regulatory reviews.

  • Gap Analysis
  • Mock Inspections
  • Audit Readiness Assessment
  • EU GMP Annex 15
  • 21 CFR 210/211
  • ICH Q10 VMP Support
FDA · EMA · ICH

Our engagement process

01

Discovery

We learn your systems, timelines, and regulatory context before scoping a single deliverable.

02

Scoping

We define the validation strategy, deliverable list, and execution timeline in a Validation Master Plan.

03

Authoring

Protocols are authored, reviewed, and approved through your quality system with full traceability.

04

Execution

We execute on-site, capturing data in real time and managing deviations as they arise.

05

Summary & Closure

Validation Summary Reports close out each phase with a defensible, inspection-ready package.

Standards we work within

§

21 CFR Part 210 & 211

US GMP regulations for finished pharmaceuticals

§

21 CFR Part 11

Electronic records and electronic signatures

EU

EU GMP Annex 15

Qualification and Validation for European market

ICH

ICH Q9 & Q10

Quality Risk Management and Pharmaceutical Quality System

ASTM

ASTM E2500

Specification, Design, and Verification of Pharmaceutical Manufacturing Systems

Flexible structures to fit your needs

Project-Based

Fixed-scope engagement with defined deliverables, timeline, and fee. Ideal for qualification campaigns, cleaning validation programs, or MES validation projects.

Staff Augmentation

On-site or hybrid engagement where our CQV Lead integrates into your team, working directly in your quality systems on an hourly or day-rate basis.

Retainer Support

Ongoing monthly engagement providing dedicated CQV expertise for regulatory readiness, change control support, and continuous validation program management.

Our Expertise

5+
Years GMP Experience
50+
Protocols Authored
3+
Facility Environments
6
Service Disciplines
100%
Senior-Led Execution

Where we've worked

🧬

Biologics & CDMO

Large-scale biologics manufacturing at contract development and manufacturing organizations, including upstream/downstream bioprocessing qualification, fermentation systems, and chromatography.

💉

Sterile Manufacturing

Aseptic fill-finish, lyophilization, vial washing and depyrogenation systems, and cleanroom environmental monitoring program support in FDA-regulated sterile facilities.

💊

Specialty Pharmaceuticals

Solid dose, liquid, and transdermal dosage form manufacturing at specialty pharma sites, including equipment qualification for coating, blending, tableting, and packaging operations.

What we know deeply

Qualification & Validation

IQ/OQ/PQ Protocol AuthoringFrom URS through final summary report with full traceability and lifecycle documentation.

Cleaning Validation ProgramsHBEL/PDE-based acceptance criteria, sampling design, recovery, and analytical method validation.

Process Validation (Stage 1–3)PPQ protocol design, process characterization, and continued process verification frameworks.

Computer System ValidationCSV for SCADA, DCS, LIMS, and MES platforms in accordance with GAMP 5.

Utility QualificationWFI, Purified Water, Clean Steam, Compressed Air, and Nitrogen qualification per USP <1231>.

Systems & Platforms

Syncade MESConfiguration verification, electronic batch record design, workflow validation, and 21 CFR Part 11 assessment.

Kneat PlatformValidation management, protocol templates, URS mapping, and execution in Kneat Gx environment.

ViewLinc Environmental MonitoringValidation of temperature/humidity monitoring systems, alarm configuration, and site expansion.

Quality Management SystemsDeviation authoring, CAPA development, and change control management in TrackWise, Veeva Vault, and site-specific QMS platforms.

HPLC & Analytical SystemsInstrument qualification for Agilent, Waters, and Thermo Fisher HPLC/UHPLC systems.

Platforms we use fluently

Syncade MES

Electronic batch records

Kneat Gx

Validation management

ViewLinc

Environmental monitoring

TrackWise

Quality management

Veeva Vault

Document management

Agilent OpenLAB

HPLC data system

Waters Empower

Chromatography data

Microsoft Office Suite

Protocol & report authoring

Let's Connect

Start a conversation

Whether you have an active project, a future need, or just want to understand what CQV consulting looks like for your facility — we'd love to hear from you. Every engagement begins with a no-obligation discovery call.

📍
Address

5051 Cary Glen Blvd, Cary, NC 27519

Email

info@aetresin.com

📞
Phone

(803) 665-3138

Response Time

Within 1 business day

🗓
Availability

Mon – Fri · 8 AM – 6 PM EST

📌
Region

RTP / National · Remote & On-Site

We respond within 1 business day.
📍 5051 Cary Glen Blvd, Cary, NC 27519 · Research Triangle Park Region